WebNov 26, 2024 · Abstract. A convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is … WebOct 24, 2024 · Mimicking the conversion of salarin C to salarin A, the trisubstituted oxazole unit embedded in the 17-membered ring underwent photooxidation on treatment with …
Macrocyclic Core of Salarin C: Synthesis and Oxidation
WebA convergent strategy for the synthesis of dideoxysalarin C (3) as a potential intermediate for the total synthesis of the marine macrolide salarin C (1) is described. WebThe synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being replaced by alkene moieties. In the key step, ring-closing metathesis exclusively afforded the (E)-product. casapulla hockessin
Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide
WebNov 12, 2013 · In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS data and Mosher’s … WebMacrocyclic Core of Salarin C: Synthesis and Oxidation. Organic Letters 2024 Journal article DOI: 10.1021/acs.orglett.8b03094 EID: 2-s2.0-85055684611. Part ... Enantioselective Total Synthesis of Terreumols A and C from the Mushroom Tricholoma terreum. Angewandte Chemie - International Edition 2016 ... WebNov 2, 2024 · The synthesis of the macrocyclic core of the cytotoxic natural product salarin C from the sponge Fascaplysinopsis sp. is described, with the two epoxides being … casanuova toskana