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Phosphopantetheine binding acp domain

WebNov 20, 2024 · Phosphopantetheine binding ACP domain; Chloramphenicol acetyltransferase-like domain superfamily; 3 more domains. Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule. Macromolecule: Linear gramicidin synthase subunit A Chains: A, B. Molecule details › ... Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase.

Phosphopantetheine - an overview ScienceDirect Topics

WebApr 10, 2024 · HIGHLIGHTS. who: Filamentous Fungi and collaborators from the National Cheng Kung University, Taiwan have published the research work: Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi, in the Journal: (JOURNAL) how: This Tet-On system was applied with A. fumigatus for inducible expression of the gene of … WebPhosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C … homes for sale wabasso beach fl https://korperharmonie.com

Phosphopantetheine - Wikipedia

WebMar 2, 2010 · Phosphopantetheine binding ACP domain Structure analysis Details Assembly composition: monomeric ( preferred) Entry contents: 1 distinct polypeptide molecule Macromolecule: Norsolorinic acid synthase Molecule details › Chain: A Length: 89 amino acids Theoretical weight: 9.43 KDa Source organism: Aspergillus parasiticus WebJan 12, 2024 · Phosphopantetheine binding ACP domain (Q24722578) InterPro Domain PP-bd_ACP IPR009081 edit Statements instance of protein domain 1 reference subclass of … WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. hire with greenheart

Molecular basis for acyl carrier protein–ketoreductase interaction in

Category:Molecular basis for acyl carrier protein–ketoreductase interaction in

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Phosphopantetheine binding acp domain

Modular type I polyketide synthase acyl carrier protein domains …

WebNov 20, 2024 · Fatty acid and phospholipid metabolism Other PAO1 genes in this class Pathways Functional Predictions from Interpro Search for additional functional domains at the NCBI CDD database website. Go to this protein's …

Phosphopantetheine binding acp domain

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WebJul 10, 2024 · ACP3 is a four-helix bundle with S38 being unmodified in the apo form of the protein, phosphopantheine bound in the holo form, and with polyketide substrate attached to the phosphopantetheine in the acyl bound form. The protein backbone is shown as ribbon, with the S38 side chain and bound substrate shown as atoms with standard CPK colorings. WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. 2 publications Catalytic activity

WebJul 5, 2024 · Sequence domains: Thioester reductase-like domain; ACP-like superfamily; Phosphopantetheine binding ACP domain; AMP-dependent synthetase/ligase domain; … WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty … Hei Sook Sul, ... Li Chen, in Progress in Nucleic Acid Research and Molecular …

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … WebJul 31, 2014 · (1) Movement of the ACP’s phosphopantetheine (Ppant) arm is thought to be coordinated with protein–protein interactions and significant rearrangement of the PKS …

WebMar 1, 2002 · Furthermore, the helical structure of ACP resembles that of 14-3-3, which suggests that this region of the enzyme may be important in ACP recognition and binding. Therefore, it is likely that the AHL synthase binds acyl-ACP first, followed by a conformational rearrangement of the N-terminal domain and SAM binding in a bi-ter …

Webthe S. cerevisiae FAS (19, 20), the missing ACP domain was subsequently located, docked to the KS domain. We have recently purified the S. cerevisiae fatty acid synthase ... third part binding the CoA or ACP phosphopantetheine group that transfers the acyl and malonyl substrates. In the large fungal fatty acid complex, the KS dimers were ... hirewithmehttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 hirewithrocketWebAcyl carrier protein (ACP) is a universal and highly conserved carrier of acyl intermediates during fatty acid synthesis. In yeast and mammals, ACP exists as a separate domain within a large multifunctional fatty acid synthase polyprotein (type I FAS), whereas it is a small monomeric protein in bacteria and plastids (type II FAS). homes for sale waco nc