WebDec 18, 2024 · DeGrado, Greenbaum, and co-workers have used thiol bis-alkylation to induce α-helical structure in a peptide inhibitor of the protease calpain [ 50 ]. The cysteine residues to be cross-linked were placed at i and (i + 4) positions within a model peptide with moderate helicity. WebFeb 16, 2010 · The structure and property of the Au DTCs are studied to probe two effects: the entropy gain of dithiol over monothiol ligand protection and the constraint to the …
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WebMay 28, 2014 · We describe an assessment of the full range of β-strand interfaces whose high-resolution structures are available in the Protein Data Bank. This analysis identifies complexes where a β-stand or β-sheet contributes significantly to binding. WebAug 16, 2010 · Upon reduction, the antitumor drug mitomycin C undergoes a cascade of reactions to give a bis-electrophile that alkylates cellular nucleophiles. We recently … commercial beer towers
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WebOct 7, 2024 · A range of different macrocycles can be rapidly accessed from the same parent peptide containing two cysteines (peptide 2) using dithiol bis-alkylation … WebDec 6, 2024 · Turan-Zitouni et al. synthesized bisthiazole derivatives 100 to study their properties as an anticancer. The preparation of these compounds was done in two steps, the first step involved the synthesis of 1,1′-(3,3′-dimethoxybiphenyl-4,4′-diyl)bis(thiourea) 98 from the reaction of 3,3′-dimethoxybiphenyl-4,4′-diamine 98 with potassium thiocyanate … WebMultiprotein complexes such as the transcriptional machinery, signaling hubs, and protein folding machines are typically composed of at least one enzyme combined with multiple non-enzymes. Often the components of these complexes are incorporated in a combinatorial manner, in which the ultimate composition of the system helps dictate the type, location, … commercial beer supplies